You need pentration. 45 ACP is a poor performer in that aspect with any load and there are not many commercial loads specifically designed for deep penetration. Could it work in a pinch, yes. There is documtation to prove it has worked at least once. Still wouldn't be my 1st choice.
It is really the bullet more than chambering for the most part. A 357, 41, 44 mag, or hot loaded 45 Colt or even 10mm loaded with heavy for caliber hardcast bullets moving as fast as possible would be my choice. The monster guns such as the 454, 460 and 500 S&W are better on paper and the handgun I'd carry if I were hunting. But for everyday carry they are just too big.