10/22. Proven, reliable, accurate, cheap to shoot, a million custom options available. Just use CCI ammo and quality mags
But for home defense I'd get a shot gun
I agree with both of BigTex's points but especially the argument for the shotgun if it's the only gun to be had for HD. Mossberg Mavericks, chambered in 12 gauge, were selling nib @ Dick's Sporting Goods for $179.99 a few weeks ago.