Wheel guns are very lefty friendly. To reload, open the cylinder latch with your trigger finger then push open the cylinder with your right thumb. The right thumb goes through the frame window and right fingers wrap around the frame to hold the cylinder open and support the rest of the gun. Right index finger pushes the ejector rod. Reload with the left hand, snap her shut with the right fingers while transfering back to the left hand and your good to go. Never tried a reload from a right hander's perspective but I don't see how it could be any faster.
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The older I get the better I was.