My first gun was, to my regret, a ruger 22/45. After 3 months, I sold it, saved up some money, and found a used S&W model 41. I have never regretted buying the 41. Since that time, I have bought and sold many, many 22s, both revolvers and autos, but none has been as satisfying as the 41.
Last year, I bought a new 7" barrel and mounted a scope on it. Mine runs like a swiss watch on federal automatch, CCI, or Eley. It does not do well with any hollow point.