I too use this caliber for all large game and some target shooting. For me it’s because it’s the only rifle I own larger then .223. For whitetail and pronghorn, I use a 120 grain Nosler Ballistic Tip over 72.0 grains of Hodgdon H4831SC. For 400-600 yard targets I use the 162 grain A-Max bullet over 70.0 grains of H4831SC. Both give less then one MOA. I keep the velocities down around the levels of a .280 or maybe a bit more. I get the best accuracy at that speed, and should get longer barrel life.