It would be good to know what you will be shooting them out of. Reason being not all .45 Colt handguns are made equal. The Colt SAA, and many of the clones of it. (Including modern ones.) Would be dangerous to fire the real hot loads out of. As well as trying to load a Ruger Black Hawk/TC Encore load in a newly made Ruger New Model Vaquero.
Lyman 49th has loads listed for strong action .45 Colt loads that would blow a weaker gun apart. Possibly injuring/killing the person shooting it, and any bystanders.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.