Do you subscribe to the high velocity/light bullet philosophy or the low velocity/heavy bullet thinking? I can't decide so I stay in the middle with 125 gr JHP +P which seems to be the best trade-off in bullet energy. One thing that makes me lean to the heavy bullet theory though is that there is no question that the .45 ACP is a reliable man stopper and I figure a slower but heavier bullet like the .38 +P 158 gr. JHP is a not-quite-as powerful analog to the .45s performance. The .357 also has a good reputation as an effective stopper but in the house I'll stick to the .38+P because I would like to keep my hearing.