My current .30-06 hunting load uses 61.0 grains of RL19 and a 150 grain Hornady SST bullet. WLR primer. This gives me 2907 fps from my Savage 110, with accuracy under 1 inch at 100 yards. This load has taken a couple of deer and acquitted itself very well.
For the .25-06, and most overbore cartridges, I use RL22, which I've found works best in cartridges with big cases relative to bore size.