Thanks for all the suggestions. I actually dug out my Speer manual and noticed the starting load for Power Pistol claims an MV very close to the MV listed on the Speer box. I think I'll start out with that b/c I like PP and I have a couple pounds in the powder magazine.
I do have a chrono, so I'll be able to check as I go. The bullets are too expensive to do an actual OCW ladder, but I can do an abbreviated version.
"I'm your huckleberry."