Cost? For the price of 20 boxes of 44 ammo you can buy a first-class basic loading setup and enough components to load those same 1,000 rounds. Or for the cost of 10 boxes of 44 you can buy a minimal setup and enough components to load 500 rounds. And the minimal setup can be expanded later.
A boring Saturday now has me looking around my house for a spot to put some reloading gear. It might be weird to reload in my bedroom but I have about a 2'x4' empty space on top of a beat up old dresser that I plan on replacing when I finally move into my bigger place.