A .22 is f'n worthless for home defense.
I wouldn't go that far.
Each round of 22LR from a 10/22 (rifle) packs close to 200 lbs of muzzle energy with the right cartridge (40gr LRN Aguila Interceptor). That's about the same energy as a 38 Special Snub with standard pressure rounds.
"With great power, there must also come great responsibility." - Stan Lee
"All that is necessary for evil to triumph is for good men to do nothing." - Edmund Burke