Some will do great at 100 yards, and then not so great at 300+. It is one of those things that you will have to experiment with. I can say I have never heard of loads that shot awful at 100 yards, and did great at 300+.
I would say if it works very well at 100 move it out, and test it.
No matter how many times you do it and nothing happens it only takes something going wrong one time to kill you.