"Nose configuration can affect seating depth and that affects powder charge. Sometimes a lot. I'm thinking, as an extreme example, of a 148 grain .38 wadcutter that has to be seated flush to the case mouth to feed in the Smith '52 or into a .357 self-loader or into some lever guns, verses a nearly same-weight 150 grain round nose bullet that sticks out and leaves a lot more powder space underneath."
True as you state it. But, the question is how much does it matter? Sticking with your example, lead bullet charges are normally significantly lighter than jacketed, especially so for deep seated wad cutters, so unless the load is on the verge of blowing up the differences in actual practice tends to be meaningless.
For full power jacketed loads a small seating depth change means very little EXCEPT for hot loaded 9mm and 10mm loads and that's because they have very small burn cavities, they use very fast powders and the bullets are typically seated very close to or in the lands. That's not true for most auto cartridges, and no revolver cartridges at all, so they aren't nearly as twitchy as the 9s and 10s. Even then the slight seating adjustments required for proper feeding of different nose configurations aren't great and not all of them can be fed through many autos anyway. Those which do matter can be corrected by dropping maybe .2 or .3 gr. of powder and normal load work up.