My (and my kids') experiences:
I own a MkIII 22/45, and have shot thousands and thousands of rounds through it, mostly el cheapo bulk stuff. It works, and is more accurate than we are. Will run dirty ( if you shoot up a bulk box of el cheapo, the gun WILL be DIRTY).
We have shot other .22 pistols, mostly borrowed at bowling pin shoots ..... the kids shot a filthy 22A at one, and it sprayed them in the arms and face with bits of powder residue when they fired it ...... not popular with the little kids.... much so that years later, daughter Jac sees that gun at the range or at the store, and says, " That gun SUCKS. It shoots crap at your face. How are you 'sposed to hit anything with crap flying at your face!?!?"
TheGolden Rule of Tool Use: "If you don't know what you are doing, DON'T."