If I didn't already own a .257 weatherby and was in the market for either the 25-06 or 7mm-08 I would likely go with the 25-06, I have always been a huge fan of the 7 rem mag and have owned one about all my life. Guess it boils down to what you plan to do with it? The 7-08 has a wider variety of bullet weights, the 25-06 is a hotrod with lighter bullets. Both will work very well on deer size game, and both are great on the target range. Again its a tough decision, buy both and make it easier!