I have to say my Smith and Wesson 581. Just a great shooter and accurate as all heck.
2nd is my Ruger sp101 in .327 federal magnum. The gun is very balanced and it does great even with full powered loads. Great gun in a great chambering.
.327 SP101, .327 Blackhawk, .45 Vaquero, Browning Maxus, Browning Silver Lightning, Ruger no.1 .243, Stoeger .410 sxs, TC Contender, Remington 870 Wingmaster, Uberti 1860, Hawken, Moisin, Mauser, Marlin 60