For casual target practice at the range, it is REALLY hard to beat the value of the Ruger MK series or the Browning Buckmark. I've heard a lot of people who feel the same way about the S&W Model 21. You can get new versions of all three for between $300 and $550, depending on options/styles.
I would LOVE to have a S&W Model 41, but I don't want to spend $1000 on a .22lr when I have shaky hands and can't maximize the accuracy potential. I'd rather have a Ruger MK II/III 22/45 and $700 worth of .22lr ammo.
I would also love to have a Hammerli or other .22lr olympic quality handgun, but I can't afford that.
I have a Mark II 22/45. It is not complicated to fieldstrip, as long as you read the manual and follow the same steps. I have it apart in less than 10 seconds. It isn't as easy as a Glock, but it is just as easy as any of my 1911s, and it doesn't require a special tool/wrench/wire unlike my 1911s.
HOWEVER, I have read that the Mark III versions are more complicated.