Autochuckers are fairly placid about POI being "generally" the same with factory loads (.45 ACP excluded), but revolvers are a whole different critter. Obviously an autoloader has to have it's ammo loaded to a certain level or it won't cycle, but a wheelgun cares not if you load a wax bullet or an Elmer Kieth Memorial Magnum.
IME, it's quite possible for different shooters to have very different POI/POA issues with fixed sight handguns. It really does not show up till you get past 10 or 15 yards or shoot at small targets. The B21 targets hide a lot of this in many organizations.