The Off Set would come with considerable practice. Accurate shot placement is the only way to ballance the scales.
Short Barrel guns are always harder to hit with, have reduced Impact Energy, and smaller Capacity than Full Size Guns. A trade off for being compact and easy to conceal.
I bought an LCR-22 quite a while back as my practice J Frame. I have shot bricks of Federal 550 pak through it. My accuracy with my 442 has improved dramaticly. Sight Picture, and Trigger Squeeze are the key elements of accuracy.