I have many handguns to choose from, both revolvers and autos, but the one I've settled on as being my perfect (no, it's not a Glock
) "nightstand" gun is my SIG Model 226. Sixteen 9mm rounds, night sights that came on the pistol and a Streamlight light/laser makes for a formidable home defense weapon if you limit yourself to a handgun. If you decide to get a revolver, I'd recommend a Smith & Wesson Model 686 + with a 4" barrel.
And welcome to The Firing Line.