I tried everything I have with my wife, but with weak hands she could not rack the slide on semi-auto pistols and recoil was too much for her. She also did not care for reloading magazines. Not even a Beretta 21A .25acp worked even though easy to load with the tip up barrel.
But the new Ruger LCR .22 LR revolver suited her very much. She can shoot it well, trigger pull is less than the SP101 and reloading is easy for her. Recoil is minimum.
Maybe not the best SD but with 8 rounds up close it should do the job. Nobody wants to get shot, not even with a .22
Just something to consider.