If a deer were coming straight at me at 50 yards, I'd probably wait for an angled shot, but never shoot for the brisket, no matter what I'd be shooting for bullet or caliber. If it kept coming at me, my shot would be higher in the neck, about the height of the backbone.
People are like rifles. Some are tried and true, having great eyes, personality, and fun to be with. Others never seem to hit the mark with you. Still others go off half-cocked. Still, it's nice to know most of them.