I don't think anybody would take the advice to make a .22 their first handgun.
But I strongly suggest it be one's second handgun.
It's how you de-flinch from the first.
I've watched newbie club shooters doing really well with the club .22s go buy a 9mm. After the first few 9mm shots they can't hit the target paper anymore. (50' bullseye targets) Switching back to .22 they still can't hit the paper until they re-focus on how they used to shoot.
I myself will switch back to the .22 when I think I might be starting to develop a flinch. It has just enough recoil to disturb your sight picture but not enough to build a flinch. Perfect for marksmanship fundamentals.