I'm with L KILLKENNY on this one! I shot a doe at 63 yards with a 180 grain Partition Gold .357 and she DRT. It was a shot right behind her shoulder, yea bullet placement...and I was seated on the ground...solid rest/platform. A .357 is more than adequate if you practice at ranges you are likely to encounter game. This Winchester factory load is rare as hen's teeth but the bullet is available for reloading, Georgia Arms sells a 158 grain Gold Dot loading for deer hunting and other commercial manufacturers loadings will also work. Don't believe for a second that only a .44, .45, .454 or .500 will work.