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Azmark: Some of my all time favorite hikes were around Sedona and the Grand Canyon. I tend to be more concerned with two legged predators than the four legged variety, even when out in the wilderness. From that perspective, just choose the caliber you shoot best. When it comes to the type of dangerous game one might encounter in Arizona, I would prefer a .357 magnum revolver or a 10 mm semi-auto pistol; but I would probably choose the .357 sig if I were selecting a conversion barrel option for your new P250.
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