Penetration is very important, probably why the .38 Special high speed LRN and SWC were better performers than the standard velocity.
Back when I carried a Model 36 S&W in an ankle holster as a BUG to my 1911. I had it loaded with +P+ 158 grain LSWC-HP. I never had to use it, but I figured those would be almost as good as my 1000 fps 200 grain SWC's that were in my .45 ACP.
"No free man shall ever be debarred the use of arms."- Thomas Jefferson