Having owned a couple of both, Id take the P226 without hesitation. The P6's are good guns, but need some attention to bring them up to speed, and they really are not all that much smaller than the P226.
Ive carried both, and never noticed a difference, and I doubt youd be able to tell if someone slipped one or the other in your holster without you looking.
“The enemy is anybody who's going to get you killed, no matter which side he is on.”
― Joseph Heller, Catch-22