Today, you either have to have adjustable sights, find the load that matches you and your sights, or get out the file.
For some purposes including completion and hunting, plinking. However, for self-defense, 25 yards is way to far away. FBI says average shooting has been 7 yards, so put your fixed-sight practice target at 7 yards and see where the bullets are going. Unless the barrel is bent, you will be hitting a 8.5x11 inch target. How are you going to explain in court that your life was in danger with an assailant 25 yards (75 feet way)? Fixed sights are for defensive
revolvers in defensive
situations. That is why they call fixed sighted two-inch barrel guns, "Belly Guns".