I've got a Model 57 now, I owned one other one in the past and a a 4 5/8th inch Blackhawk. The .41 is a good cartridge and I hope my first post didn't make people who like it think I didn't.
I have 230 grain Keith types and 210 grain Gold Dots for my 41, which are great bullets and do basically the same thing the 240 grain Gold Dot and 250 grain Keith Type .44s do. So just those two bullets alone could take you along way. If you couldn't kill it with those, you'd probably have to go bigger than the .44 too.