Realistically, most of us would likely have to defend ourselves from wherever we happen to be at the time.
Yes, virtually every expert recommends getting everyone into a saferoom if possible, but that strategy is dependent upon being able to get there in time.
Your floor plan does seem to lend itself to that strategy better than most.
Every violent burglary of an occupied residence that I can remember having happened around here in the last few years involved two or more invaders and occurred during the daylight hours. Most of the entries occurred with no warning and little time to react.
Keep your contingency plans varied and flexible.