well the 44 Mag sure offers more platforms and variety of ammo to choose from.
You can shoot 44 Specials in it. You will find ammo in stock most of the time(even wal-mart).
The 41 is rather cult-ish but a top performer and a handloaders dream as their are lots of bullets to choose from.
You can load pipsqueaks to Bruisers and take a lot of game within reasonable ranges. That said I have two 41's and no 44's.
That Cajun's 44 special is NICE !!