I don't have any experience with the Ruger Six series. I am curious about Speed Sixes, but have rarely seen one.
That said, I've owned quite a few revolvers. The 3" 65 is right at the top of my list of all-around revolvers. It's fairly easy to carry and conceal; it points beautifully; and it is very accurate.
I removed the factory hammer from mine, and had a bobbed hammer installed. The DA trigger is very smooth, and I have no trouble shooting the gun DA only at 25 yards. At 7 yards, it barely requires aiming. I also added some Ahrends' finger-groove wood grips. (The original hammer and grips are in the original box.)
I usually carry autos, but when I am in the mood for a medium frame revolver, the 65 is first choice.