If you're referring to the Mark I,II,III Rimfire Pistols, then no. They're blow back actions. I can't see anyway for Ruger to redesign it to accommodate a bolt of larger mass with a heavier recoil spring to safely handle centerfire pressures without the upper receiver becoming big and ugly like a HiPoint. After such modifications I doubt you'd buy it as it wouldn't resemble a Mark series pistol anymore.
"THE CONSTITUTION ONLY GIVES PEOPLE THE RIGHT TO PURSUE HAPPINESS, YOU HAVE TO CATCH IT YOURSELF." ~BENJAMIN FRANKLIN.