One shot stop statistics are nice ways to compare relative effectiveness of rounds, but my personal belief is to shoot until the threat goes away.
I'm not a fan of "one shot stop" statistics.
I've seen too many deer and other critters run 100 yards or more after having their lung/heart turned to jelly.
Seen it with people too.
With deer and such, you can tell if it was a good hit by the reaction,....just give them a bit of time.
With something that is trying to hurt you, keep shooting until they keep flooping.