The hornady V-Max is designed to break up on impact and they impart a whole lot of energy into a target when they do. It will either make a violent exit wound, or it won't exit the target at all.
.223 v-max on a squirrel or prairie dog = exploding prairie dog or squirrel
.223 v-max on a coyote or anything larger, it might not exit but it will do massive internal organ damage.
I don't shoot .45 ACP, but i would trust a .223 more for hunting any day of the week. I don't know that i would use it on something like deer, but the v-max round is a killer in any caliber.