Keep in mind the new Ruger 45C flattops won't handle "Ruger Only Loads". The 44 spl flattops will handle the Skeeter load very well. In fact, a lot of reports of people going beyond that and doing fine. I stop at the 7.5 gr of Unique in the Skeeter load. It's a tack driver with that one.
I don't see how you can go wrong with either the 44 spl or 45C.