I have a pair of Jay Scott imitation stag grips on my Ruger Single Six. They have been there for more than 40 years and I like them. Looks and usefulness both. I have carried this hunting, hiking and working on the farm. The irregular surface of the grips always gave me a good......er......grip.
I like the looks of other materials also, those mesquite are quite attractive. But, for me, on this gun, these are the way to go.