I'd probably go for the .44 Special
I already reload for it and don't for the .45 Colt. Elmer Keith said the .45 Colt was better if one stuck to factory ammo, and the .44 Special was better for a reloader. Of course, the Ruger single actions didn't exist when he formed that opinion, but I like Elmer.
I would also prefer the shorter barrel. The longer barrel gets more horsepower from the loading - any loading - but the shorter barrel is nearly as fast and much easier to holster and carry.