not all accuracy
The above mentioned Mossberg 800 will stack 85 gr (?) factory poly tipped varmint slugs in spooky sub MOA groups.......but I will not shoot a deer with a coyote bullet.
The Noslers go about 1.5", but I would not hesitate on a quartering shot on any whitetail with the combo.
I think the "any bullet" theory is what gets the .243 its bad knocks. Above .25 caliber, you can get away with light bullet construction on most deer. With the .243, I believe it becomes more important.