You will get many different answers on your post and all of the info will probably be helpful. Sometimes it boils down to personal preference. As far as deer hunting I have taken more deer with the 30.06 than any other caliber. For some reason I have always used 180 grain bullets and tried some 165's one time. The 180's might be more than whats needed, but most of my hunting is in thick dense woods with shots from 20 feet to maybe 80 yards if I am lucky. I must say if you do your job the 180's will put down deer like a sledge hammer. Try some good factory rounds, Federal Fusions are great, Hornady ammo and some of the others will also do just fine.
If you get set up reloading your own it will be a big plus.