This 105 gr VLD was going a lot slower than 2700 fps at impact and worked just fine. Nothing wrong with a 243.
Sometimes you run across animals that just don't want to die. Hunt long enough and you will run across one. I've put a 165 gr Nosler ballistic tip through both lungs of a mature whitetail that left a 2" exit hole. He still ran over 100 yards. Shot a 260 lb black bear that dropped in his tracks with the same bullet. Go figure.
I'd use that gun and load combination on any deer, at any range I am capable of shooting.