I typically use my 357 magnum Marlin lever action... Why? Its cause I am best with it. It is a trapper model with a 16 inch barrel and it very small and light and handy. I have shot it since I was a child. I have taken many deer with it as well as lots of plinking and small game.
I believe in using what you are best with.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 21 of my guns are 45/70 govt 357 mag, 22 or 12 ga... I believe in keeping it simple