In reference to defensive handguns: "They all suck, so pick the one you shoot best."
This is probably one of the most accurate statements I have read in recent memory. With very few exceptions, a handgun is primarily a defensive weapon, although still very lethal.
I take heat now and then for my choice of the 9mm, I have become immune to it, I just shrug my shoulders and say "Okay" or something and let the him think he got me. If He/she values their own opinion so much to attack my caliber choice, there is very little point in me showing my disagreement of it.