Three times in my life I have had to produce a firearm in self-defense. Never fired. Bad guys are not very smart, but they are smart enough to know they do not want to be shot with any gun. In all three of those instances the gun I used was a Ruger Single Six in .22 lr.
My carry is a Walther style .22 lr.
Now, if I frequented dark alleys populated by 250 pound druggies my choice might be different. But, I don't.