I do have two .357's; I forgot them in my original post but mentioned them in a following post (they are a 686 and a Blackhawk).
Yes, I am a little light on the .22's. I enjoy the Buck Mark and have considered a wheel gun, mainly for teaching the kids to shoot once they are old enough.
A P220 has crossed my mind, as has the possibility of selling a piece or two, saving some coin, and picking up a Les Baer (probably something like a Concept V or Premier II.
I'm not hugely interested in adding more calibers to my collection. I'm not entirely opposed to it either, but having a few "standard" calibers that meet my needs makes life easier.
Thanks for the ideas, everyone!