It depends on what your home defense strategy is and what other non-firearm measures you've taken.
In my case it involves holing up in a bedroom behind cover and not moving to clear the house. I play the odds that any robbery or burglary, while I am at home, will be after my wife and I go to bed.
The odds of a daylight robbery, while I am at home, is smaller than the chance of shark attack.
If I had to maneuver through the house I might develop a strategy that used a hand gun. At present I don't feel that need.