On second thought, the crappy BC of those pellets that are light enough to hit those .22 rimfire velocitys can be a safety factor if you are shooting squirrels in trees. These pellets shed velocity like birdshot and that is important in a semi-rural area where you have neighbors in all directions.
A 6.5 grain wadcutter with a .01 BC starting out at 1200 fps is going less than 100 fps at 200 yards. Like a shotgun shooting birdshot, it probably won't go a quarter mile at any elevation angle.
If you have neighbors close enough for the sound of a .22 to be a problem, you definitely have neighbors close enough for the danger zone of a .22 to be a problem.