I have handguns, and use them for either CCW or home defense, in 9mm, .40S&W, .45ACP, .380, .38spl (+P), .357mag, and .45LC. I will probably buy a .327 Federal Mag. I don't personally care for it, but there is nothing wrong with .357SIG either.
There is a place for every major defensive caliber. They all have different advantages and disadvantages, and all 9mm and up will have pretty comparable success in stopping attackers with proper ammo selection. There really isn't enough difference to be worth an argument.