Probably depends on the ammo.
For instance, Aguila makes a 60 grain sub-sonic load that uses a .22 short case to compenssate for the loooong bullet, which is considered a LR load (same length as a LR).
I have used these in my henry .22, but I guess that the speed they come out of the barrel and whatever twist rate my rifle had just didn't agree with the 60g subsonic short cased long rifle. They tumbled and I was getting keyhole impacts. Wasn't getting enough rotation to stabilize it.
Your mileage may vary.