I was once advised to shoot148g Full wadcutters exclusively for self defense loads.
Very bad advice, unless you are attacked by sheets of paper. A soft lead slug traveling anywhere from 650-700 fps are only going to make someone angry. I saw lots of inner city folks and a few cops shot with them. One memorable one, was a friend shot in the pelvis, bullet hit his pelvis and stopped dead, he shot the BG 6 times with his 357, sat down reloaded and waited for the cavalry.